Type I Glanzmann thrombasthenia: Most common subtypes in North Indians
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چکیده
منابع مشابه
Glanzmann thrombasthenia
Glanzmann thrombasthenia (GT) is a rare autosomal recessive bleeding syndrome affecting the megakaryocyte lineage and characterized by lack of platelet aggregation. The molecular basis is linked to quantitative and/or qualitative abnormalities of alphaIIb beta3 integrin. This receptor mediates the binding of adhesive proteins that attach aggregating platelets and ensure thrombus formation at si...
متن کاملGlanzmann thrombasthenia in a neonate.
Glanzmann thrombasthenia is a qualitative platelet function disorder manifested by skin bleeds, epistaxis, gingival bleeding, gastrointestinal hemorrhage, hematuria, hemarthrosis, intracranial hemorrhage and visceral hematomas. We report a six day old newborn presenting with hematuria following suprapubic aspiration, who was diagnosed as Glanzmann thrombasthenia. We believe it to be the younges...
متن کاملGlanzmann Thrombasthenia: A Clinicopathological Profile.
OBJECTIVE To describe the clinical presentation of patients with Glanzmann's thrombasthenia (GT) and evaluate their diagnostic, clinical, and laboratory parameters including platelet aggregometry. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Hematology and Blood Transfusion, The Children Hospital and Institute of Child Health, Lahore, from January 2006 to Decemb...
متن کاملType I Glanzmann Thrombasthenia Patients From the Iraqi - Jewish and Arab Populations in Israel Can Be
A sensitive immunoblot technique for platelet glycoprotein lIla (GPllla) was used to analyze the platelets of patients living in Israel who meet the diagnostic criteria for type I Glanzmann thrombasthenia. When reacted with solubilized normal platelets, a rabbit antiserum to GPIIIa identified a major band at molecular weight (mol wt) 90.000 and three additional minor bands at Mr 1 1 0.000. 81 ....
متن کاملType I Glanzmann Thrombasthenia Patients From the Iraqi - Jewish and Arab Populations
A sensitive immunoblot technique for platelet glycoprotein lIla (GPllla) was used to analyze the platelets of patients living in Israel who meet the diagnostic criteria for type I Glanzmann thrombasthenia. When reacted with solubilized normal platelets, a rabbit antiserum to GPIIIa identified a major band at molecular weight (mol wt) 90.000 and three additional minor bands at Mr 1 1 0.000. 81 ....
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2003
ISSN: 0361-8609,1096-8652
DOI: 10.1002/ajh.10395